Temidayo Ogunneye died after being stabbed behind a block of flats in Cormont Road, Camberwell, on Wednesday.
Kieron Carew-Donaldson, 18, of Brixton, and Darius Kwakye, 18, of Camberwell, were both charged with murder and also two counts of robbery.
They, along with the girl who cannot be named for legal reasons, are to appear at Sutton Magistrates' Court on Monday.
Temidayo was the fifth teenager to be fatally stabbed in London this year.
He died six hours after being taken to hospital and post-mortem tests showed the cause of death to be loss of blood from stabbing injuries.
Another boy who was arrested on suspicion of murder was released on Thursday without charge.
A fourth teenage boy was arrested on suspicion of murder. He has since been released on bail.
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